Effect of 12-week High Intensity Interval Training Program on C-Reactive Protein and Insulin Resistance in Women with Polycystic Ovary Syndrome
Published: September 1, 2019 | DOI: https://doi.org/10.7860/JCDR/2019/41203.13106
Bahar Faryadian, Vahid Tadibi, Naser Behpour
1. PhD, Department of Sport Physiology, Kermanshah Branch, Islamic Azad University (IAU), Kermanshah, Iran.
2. Associate Professor, Razi University, Kermanshah, Iran.
3. Assistant Professor, Razi University, Kermanshah, Iran.
Correspondence
Bahar Faryadian,
PhD, Department of Sport Physiology, Kermanshah Branch, Islamic Azad University (IAU), Kermanshah, Iran.
E-mail: faryadian.b@gmail.com
Introduction: Polycystic ovary syndrome (PCOS) is associated with metabolic derangements including insulin resistance which causes dyslipidemia and glucose intolerance. In addition, low-grade inflammation reflected by elevated serum High-sensitivity C-Reactive Protein (hs-CRP) levels is common in PCOS patients. Non-pharmacological interventions such as exercise training can play an important role in reducing insulin resistance and inflammatory markers.
Aim: To determine the effect of 12-weeks of High Intensity Interval Training (HIIT) program on insulin resistance and hs-CRP in women with PCOS.
Materials and Methods: In this Quasi-experimental study, 24 female patients with PCOS were included and divided into two groups {HIIT (12 cases) and control group (12 cases)}. HIIT consisted of three sessions for 12-weeks of intense anaerobic exercise with short periods (4 minutes) to reach 90% of maximal heart rate for 2 sessions and 1 session with moderate exercise to reach 70% of maximal heart rate. The control group resumed normal daily life without any intervention. Serum hs-CRP and fasting glucose and insulin levels were measured at baseline and after 12-weeks and HOMA-IR was calculated. Paired t-test was used to compare the measured continuous variables.
Results: Mean (±SD) HOMA-IR in HIIT group decreased from 3.22 (±1.72) to 1.99 (±0.66); p=0.001. Mean (±SD) serum hs-CRP level in HIIT group decreased from 6.3 (±1.41) to 4.7 (±1.25) mg/L; p=0.033. No significant decrease was seen in control group.
Conclusion: HIIT is associated with improvement of insulin resistance and decrease in hs-CRP in PCOS patients. This exercise training can be used as early intervention in PCOS patients.
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